Automated Quantitative CD8+ Tumor-Infiltrating Lymphocytes and Tumor Mutation Burden as Independent Biomarkers in Melanoma Patients Receiving Front-Line Anti-PD-1 Immunotherapy.
Dylan FortmanArivarasan KarunamurthyDouglas HartmanHong WangLindsey SeighIbrahim AbukhiranYana G NajjarLiron PantanowitzHassane M ZarourJohn M KirkwoodDiwakar DavarPublished in: The oncologist (2024)
An automatic digital analysis algorithm provides a standardized method to quantify CD8+ TIL density, which predicts response to front-line anti-PD-1 therapy. CD8+ TIL density and TMB are independent predictors of response to anti-PD-1 blockade.