Light-activated quantum dot potentiation of antibiotics to treat drug-resistant bacterial biofilms.
Dana F StamoPrashant NagpalAnushree ChatterjeePublished in: Nanoscale advances (2021)
CdTe-2.4 eV quantum dots (QDs) show excellent efficacy due to their tunability and photo-potentiation for sterilizing drug-resistant planktonic cultures without harming mammalian cells but this QD fabrication has not been tested against biofilms. While the QD attack mechanism-production of superoxide radicals-is known to stimulate biofilm formation, here we demonstrate that CdTe-2.4 eV QD-antibiotic combination therapy can nearly eradicate Escherichia coli , methicillin-resistant Staphylococcus aureus , and Pseudomonas aeruginosa biofilms. CdTe-2.4 eV QD versatility, safety, and ability to potentiate antibiotics makes them a potential treatment strategy for biofilm-associated infections.
Keyphrases
- drug resistant
- quantum dots
- biofilm formation
- candida albicans
- combination therapy
- methicillin resistant staphylococcus aureus
- pseudomonas aeruginosa
- staphylococcus aureus
- acinetobacter baumannii
- multidrug resistant
- escherichia coli
- sensitive detection
- cystic fibrosis
- energy transfer
- hydrogen peroxide
- molecularly imprinted
- mass spectrometry
- high resolution
- nitric oxide