Heterogeneity of CFTR modulator-induced sweat chloride concentrations in people with cystic fibrosis.
E T ZemanickI EmermanM McCrearyN Mayer-HamblettM N WardenK Odem-DavisD R VanDevanterC L RenJ YoungM W Konstannull nullPublished in: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (2024)
Post-modulator SC concentration heterogeneity was observed among all genotypes and modulators, including ETI. The presence of PwCF with post-modulator SC concentrations within the CF diagnostic range suggests room for additional treatment-associated CFTR restoration in this population.