Chemopreventive and hepatoprotective effects of genistein via inhibition of oxidative stress and the versican/PDGF/PKC signaling pathway in experimentally induced hepatocellular carcinoma in rats by thioacetamide.
Yousra M El-FarAhmed E KhodirZiad A EmarahMohamed A EbrahimMohammed M H Al-GayyarPublished in: Redox report : communications in free radical research (2022)
Genistein exerted antitumor and antioxidant effects and therefore suppress HCC development via inhibition of the PDGF/versican bidirectional axis, suppressing both ERK1 and PKC as downstream regulators. Therefore, genistein is a potential novel therapeutic candidate for improving the outcome of patients with HCC.
Keyphrases
- signaling pathway
- oxidative stress
- diabetic rats
- pi k akt
- induced apoptosis
- smooth muscle
- vascular smooth muscle cells
- epithelial mesenchymal transition
- dna damage
- high glucose
- ischemia reperfusion injury
- cell proliferation
- transcription factor
- anti inflammatory
- liver fibrosis
- risk assessment
- endoplasmic reticulum stress
- human health
- heat shock