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Thermoresponsive DNA by Intercalation of dsDNA with Oligoethylene-Glycol-Functionalized Small-Molecule Intercalators.

Debaditya BeraLars VerdonckMathias GlassnerAnnemieke MadderRichard Hoogenboom
Published in: Macromolecular rapid communications (2019)
Thermoresponsive polymeric materials are important building blocks for smart materials. In this work, the transformation of dsDNA into a thermoresponsive polymer is reported by intercalation of short, oligoethylene-glycol-modified proflavine intercalators. The thermoresponsiveness of the dsDNA-intercalator complex originates from the heating-induced dehydration of the ethylene glycol side chains, which leads to aggregation of the intercalated dsDNA. This work demonstrates the possibility of designing small-molecule intercalators to prepare thermoresponsive dsDNA complexes with tunable lower critical solution temperature behavior.
Keyphrases
  • small molecule
  • protein protein
  • single molecule
  • mass spectrometry
  • cancer therapy
  • endothelial cells
  • drug release
  • solid state