Characterization of the taste receptor-related G-protein, α-gustducin, in pancreatic β-cells.

Haruhide UdagawaMasaki HiramotoMiho KawaguchiTakashi UebansoMica Ohara-ImaizumiTakao NammoWataru NishimuraKazuki Yasuda

Published in: Journal of diabetes investigation (2020)

α-Gustducin is involved in the regulation of cyclic adenosine monophosphate, intracellular calcium levels and insulin secretion in pancreatic β-cells in a manner independent of taste receptor signaling. α-Gustducin might play a novel role in β-cell physiology and the development of type 2 diabetes.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
single cell
oxidative stress
signaling pathway
reactive oxygen species