c-Jun NH2 -Terminal Protein Kinase Phosphorylates the Nrf2-ECH Homology 6 Domain of Nuclear Factor Erythroid 2-Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen-Induced Liver Injury in Mice.

Yiping ChenKaihua LiuJingwen ZhangYan HaiPeng WangHongyan WangQiuyan LiuCatherine C L WongJun YaoYang GaoYijiao LiaoXiuwen TangXiu Jun Wang

Published in: Hepatology (Baltimore, Md.) (2021)

Mass spectrometric analysis identified serine 335 in the SDS1 region of mNrf2 as the major phosphorylation site for modulation of Nrf2 ubiquitylation by P-JNK. This study demonstrates that Nrf2 is a target of P-JNK in AILI. Our finding may provide a strategy for the treatment of AILI.

Keyphrases

protein kinase
nuclear factor
oxidative stress
toll like receptor
induced apoptosis
signaling pathway
cell death
genome wide
type diabetes
room temperature
dna methylation
transcription factor
gene expression
endoplasmic reticulum stress
combination therapy
adipose tissue
insulin resistance