Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells.

Mingtian CheSoo-Mi KweonJia-Ling TeoYate-Ching YuanLaleh G MelstromRichard T WaldronAurelia LugeaRaul A UrrutiaStephen J PandolKeane K Y Lai

Published in: Cancers (2020)

CBP/β-catenin antagonism represents a novel therapeutic strategy for suppressing PSC activation and may be effective at countering PSC promotion of pancreatic cancer.

Keyphrases

induced apoptosis
epithelial mesenchymal transition
cell proliferation
papillary thyroid
signaling pathway
cell cycle arrest
oxidative stress
cancer therapy
endoplasmic reticulum stress
cell death
young adults
childhood cancer
lymph node metastasis