High-fat diet prevents the development of autoimmune diabetes in NOD mice.
Amy L ClarkZihan YanSophia X ChenVictoria ShiDevesha H KulkarniAbhinav DiwanMaria S RemediPublished in: Diabetes, obesity & metabolism (2021)
This study shows that HFD protects NOD mice from autoimmune diabetes and preserves beta-cell mass and function through alterations in gut microbiome, increased T-regulatory cells and decreased insulitis. Further studies into the exact mechanism of HFD-mediated prevention of diabetes in NOD mice could potentially lead to interventions to prevent or delay T1D development in humans.
Keyphrases
- high fat diet
- insulin resistance
- high fat diet induced
- type diabetes
- cardiovascular disease
- adipose tissue
- glycemic control
- multiple sclerosis
- induced apoptosis
- single cell
- transcription factor
- innate immune
- metabolic syndrome
- physical activity
- density functional theory
- signaling pathway
- cell proliferation
- endoplasmic reticulum stress