Histone Methyltransferases SUV39H1 and G9a and DNA Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after Photothrombotic Stroke.
Svetlana SharifulinaValentina A DzreyanValeria GuzenkoDemyanenko S VPublished in: International journal of molecular sciences (2021)
Thus, the data obtained show that DNA methyltransferase DNMT1 and histone methyltransferase G9a can be potential protein targets in ischemic penumbra cells, and their inhibitors are potential neuroprotective agents capable of protecting penumbra cells from postischemic damage to the cerebral cortex.
Keyphrases
- dna methylation
- cerebral ischemia
- circulating tumor
- induced apoptosis
- cell free
- single molecule
- subarachnoid hemorrhage
- atrial fibrillation
- oxidative stress
- gene expression
- human health
- cell cycle arrest
- spinal cord
- functional connectivity
- blood brain barrier
- big data
- risk assessment
- machine learning
- nucleic acid
- small molecule
- signaling pathway
- cell death
- spinal cord injury
- pi k akt