Smaller anterior hippocampal subfields in the early stage of psychosis.
Maureen McHugoMaxwell J RoeskeSimon N VandekarKristan ArmstrongSuzanne N AveryStephan HeckersPublished in: Translational psychiatry (2024)
Hippocampal volume is smaller in schizophrenia, but it is unclear when in the illness the changes appear and whether specific regions (anterior, posterior) and subfields (CA1, CA2/3, dentate gyrus, subiculum) are affected. Here, we used a high-resolution T2-weighted sequence specialized for imaging hippocampal subfields to test the hypothesis that anterior CA1 volume is lower in early psychosis. We measured subfield volumes across hippocampal regions in a group of 90 individuals in the early stage of a non-affective psychotic disorder and 70 demographically similar healthy individuals. We observed smaller volume in the anterior CA1 and dentate gyrus subfields in the early psychosis group. Our findings support models that implicate anterior CA1 and dentate gyrus subfield deficits in the mechanism of psychosis.
Keyphrases
- early stage
- high resolution
- bipolar disorder
- protein kinase
- cerebral ischemia
- palliative care
- magnetic resonance
- traumatic brain injury
- squamous cell carcinoma
- photodynamic therapy
- blood brain barrier
- neoadjuvant chemotherapy
- tandem mass spectrometry
- amino acid
- locally advanced
- fluorescence imaging
- liquid chromatography