Predicting drug response from single-cell expression profiles of tumours.

Simona PellecchiaGaetano ViscidoMelania FranchiniGennaro Gambardella

Published in: BMC medicine (2023)

DREEP provides an in silico framework to prioritize drugs from single-cell transcriptional profiles of tumours and thus helps in designing personalized treatment strategies and accelerating drug repurposing studies. DREEP is available at https://github.com/gambalab/DREEP .

Keyphrases

single cell
rna seq
high throughput
drug induced
gene expression
adverse drug
transcription factor
molecular docking
case control
oxidative stress