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Predicting drug response from single-cell expression profiles of tumours.

Simona PellecchiaGaetano ViscidoMelania FranchiniGennaro Gambardella
Published in: BMC medicine (2023)
DREEP provides an in silico framework to prioritize drugs from single-cell transcriptional profiles of tumours and thus helps in designing personalized treatment strategies and accelerating drug repurposing studies. DREEP is available at https://github.com/gambalab/DREEP .
Keyphrases
  • single cell
  • rna seq
  • high throughput
  • drug induced
  • gene expression
  • adverse drug
  • transcription factor
  • molecular docking
  • case control
  • oxidative stress