Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers.
Karolina WołodkoJuan E Castillo-FernandezGavin KelseyAntónio Miguel GalvãoPublished in: International journal of molecular sciences (2021)
The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women.
Keyphrases
- adipose tissue
- insulin resistance
- weight loss
- pregnancy outcomes
- metabolic syndrome
- high fat diet induced
- type diabetes
- polycystic ovary syndrome
- birth weight
- high fat diet
- multiple sclerosis
- weight gain
- healthcare
- physical activity
- bariatric surgery
- early onset
- obese patients
- pregnant women
- human health
- risk assessment
- drug induced