Resveratrol Stimulates Hydrogen Sulfide (H2 S) Formation to Relax Murine Corpus Cavernosum.

Gunay Yetik AnacakMehmet V DereliGulnur SevinOzge OzzayımYasemin EracAsif Ahmed

Published in: The journal of sexual medicine (2015)

These results demonstrate that RVT-induced relaxation is at least partly dependent on H2 S formation and acts independent of eNOS pathway. In phosphodiesterase 5 inhibitor (PDE-5i) nonresponder population, combination therapy with RVT may reverse erectile dysfunction via stimulating endogenous H2 S formation.

Keyphrases

combination therapy
endothelial cells
high glucose
diabetic rats
pi k akt
nitric oxide synthase
cell proliferation
signaling pathway