White matter hyperintensity topography in Alzheimer's disease and links to cognition.
Antoine Garnier-CrussardSalma BougachaMiranka WirthSophie DautricourtSiya SherifBrigitte LandeauJulie GonneaudRobin De FloresVincent de la SayetteDenis VivienPierre Krolak-SalmonGaëlle ChételatPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2021)
WMH specifically contribute to lower cognition in AD, independently from amyloid deposition and atrophy. This study emphasizes the clinical relevance of WMH in AD, especially posterior WMH, and most notably S-CC WMH.