Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment.
Tonny LagerweijSophie A DusoswaAdrian NegreanEsther M L HendrikxHelga E de VriesJeroen KoleJuan J Garcia-VallejoHuibert D MansvelderW Peter VandertopDavid P NoskeBakhos A TannousRené J P MustersYvette van KooykPieter WesselingXi Wen ZhaoThomas WurdingerPublished in: Angiogenesis (2017)
Optical tissue clearing opens new avenues for combined quantitative and 3D microscopic analysis of the topographical relationship between GBM cells and their microenvironment.
Keyphrases
- high resolution
- induced apoptosis
- high speed
- cell cycle arrest
- mass spectrometry
- white matter
- resting state
- single molecule
- oxidative stress
- cell proliferation
- signaling pathway
- endoplasmic reticulum stress
- cell death
- multiple sclerosis
- photodynamic therapy
- brain injury
- energy transfer
- blood brain barrier
- subarachnoid hemorrhage