Brain 5-HT1A Receptor PET Binding, Cortisol Responses to Stress, and the Familial Transmission of Suicidal Behavior.

Nadine M Melhem Yongqi ZhongJeffrey M MillerFrancesca ZanderigoR Todd OgdenM Elizabeth SubletteMadison NewellAinsley BurkeJohn G KeilpMohammad LesanpezeshkiElizabeth BartlettDavid A BrentJ John Mann

Published in: The international journal of neuropsychopharmacology (2021)

5-HT1A receptor binding in ROIs was not linked to familial risk or resilience protecting against suicidal behavior or mood disorder although it may be related to lethality of suicide attempt. Future studies are needed to better understand the biological mechanisms implicated in familial risk for suicidal behavior and how HPA axis function influences such risk.

Keyphrases

depressive symptoms
early onset
binding protein
climate change
positron emission tomography
case control
heat stress