Coexistence of superficial carcinogenesis of resident epithelium besides neuroendocrine neoplasm of the digestive tract.

Hiroyuki KuwanoTakehiko YokoboriMunenori IdeHiroshi SaekiMakoto SohdaMakoto SakaiTomonori YoshidaKengo KuriyamaKyoichi OgataHiroomi OgawaTakuhisa OkadaTatsuya MiyazakiShunsuke TakahashiKen Shirabe

Published in: Cancer medicine (2022)

These findings suggested a potential "paratransformation" or "bystander effect" in resident epithelium by NENs. Thus, "bystander carcinogenesis" could be a pathogenic mechanism of resident epithelium transformation adjacent to NENs in the esophagogastrointestinal tract.

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