Effects of Photoperiod on Acetaminophen-Induced Hepatotoxicity in Mice.

Jihong LuHu WangRumeng ZhangZhikang WanHang GaoJie CaiYujia ChengDong PuTengfei LinChenyu FanYing Sun

Published in: Digestive diseases and sciences (2019)

APAP-induced hepatotoxicity can be mediated by photoperiod through the circadian gene Per2, suggesting that medicines containing APAP should be administered not only with food but also according to the appropriate photoperiod.

Keyphrases

drug induced
liver injury
high glucose
diabetic rats
oxidative stress
genome wide
gene expression
type diabetes
dna methylation
high fat diet induced
adipose tissue
genome wide identification