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Azathioprine metabolite levels and outcomes during pregnancies with rheumatic disease.

Stephen J BalevicCatherine A SimsAmanda M EudyValerie SmithMegan E B Clowse
Published in: Lupus science & medicine (2024)
In this exploratory study, we did not observe systematic changes in 6-TGN concentrations throughout pregnancy and peripartum, whereas 6-MMPN concentrations were higher during pregnancy. Monitoring AZA metabolite concentrations in pregnancy is a potential tool to identify medication non-adherence as well as patients with high 6-MMPN in whom dosage adjustment or close laboratory monitoring may optimise safety.
Keyphrases
  • preterm birth
  • pregnancy outcomes
  • rheumatoid arthritis
  • healthcare
  • type diabetes
  • pregnant women
  • glycemic control
  • adipose tissue
  • metabolic syndrome
  • climate change
  • electronic health record