The effect of SGLT2 inhibition on brain-related phenotypes and aging: a drug target Mendelian randomization study.

Zhihe ChenXueyan WuQianqian YangHuiling ZhaoHui YingHaoyu LiuChaoyue WangRuizhi ZhengHong LinShuangyuan WangMian LiTian-Ge Wang Zhi-Yun Zhao Yanan HouYuhong ChenYu Xu Jie-Li Lu Yanqiu Wang Wei-Qing Wang Shan Luo Shiu Lun Ryan Au Yeung Yu-Fang Bi Yufang Bi

Published in: The Journal of clinical endocrinology and metabolism (2024)

Our study supported that SGLT2 inhibition increases father's attained age, cognitive function and intelligence, which was mediated through brain images of different brain regions. Future studies are needed to investigate whether similar effect could be observed for users of SGLT2 inhibitors.

Keyphrases

resting state
white matter
functional connectivity
cerebral ischemia
multiple sclerosis
convolutional neural network
blood brain barrier
machine learning