PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity.

Taira MayanagiHiroki YasudaKenji Sobue

Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)

PSD-Zip70 deficiency causes behavioral defects in working memory and cognition, and enhanced anxiety due to prefrontal hypofunction. This study revealed that PSD-Zip70 plays essential roles in glutamatergic synapse maturation via modulation of the Rap2 activity in the PFC. PSD-Zip70 interacts with both SPAR (spine-associated RapGAP) and PDZ-GEF1 (RapGEF) and modulates the Rap2 activity in postsynaptic sites. Our results provide a novel Rap2-specific regulatory mechanism in synaptic maturation involving PSD-Zip70.

Keyphrases

working memory
transcranial direct current stimulation
attention deficit hyperactivity disorder
functional connectivity
transcranial magnetic stimulation
single cell
depressive symptoms
replacement therapy
sleep quality
binding protein
smoking cessation