Serologic extracellular matrix remodeling markers are related to fibrosis stage and prognosis in a phase 2b trial of simtuzumab in patients with primary sclerosing cholangitis.
Douglas ThorburnDiana J LeemingWilliam T BarchukYa WangXiaomin LuVladislav A MalkovKaori L ItoChristopher L BowlusCynthia LevyZachary GoodmanMorten A KarsdalAndrew J MuirJun XuPublished in: Hepatology communications (2024)
Pro-C3 correlated with fibrosis stage, and Pro-C3 and ELF score provided discrimination of advanced fibrosis and cirrhosis and predicted PSC-related events and fibrosis progression. The results support the clinical utility of Pro-C3 and ELF score for staging and as prognostic markers in PSC.