Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling.

Roberto PaneLoubna LaibKarina FormosoMaximin Détrait Yannis Sainte-MarieFlorence BourgailhNolan Ruffenach Hanamée FaugerasIlias SimonEmeline Lhuillier Frank Lezoualc'h Caroline Conte

Published in: Circulation research (2023)

Our study reveals an unsuspected epigenetic mechanism of CaN that directly regulates MLL3 histone methyl transferase activity to promote cardiac remodeling.

Keyphrases

acute myeloid leukemia
dna methylation
left ventricular
gene expression
protein protein