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Novel prodrugs of decitabine with greater metabolic stability and less toxicity.

Naoko HattoriMagoichi SakoKana KimuraNaoko IidaHideyuki TakeshimaYoshitaka NakataYutaka KonoToshikazu Ushijima
Published in: Clinical epigenetics (2019)
We developed two novel prodrugs of DAC that exhibited greater stability, comparable DNA demethylation activity, and less toxicity. These compounds are expected to overcome the difficulty in achieving stable pharmacokinetics in patients, leading to maximum DNA demethylation activity with minimum adverse effects.
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