Splenectomy Promotes Macrophage Polarization in a Mouse Model of Concanavalin A- (ConA-) Induced Liver Fibrosis.

Yongjuan WangXiaopei GuoGuohui JiaoLili LuoLu Zhou Jie ZhangBangmao Wang

Published in: BioMed research international (2019)

Splenectomy may promote the polarization of CD11b+Ly6Chigh MDSCs and the differentiation of M2 macrophages while restricting the level of NF-κB p65-p50 heterodimers. These factors may suppress the progression of liver fibrosis.

Keyphrases

liver fibrosis
mouse model
high glucose
signaling pathway
diabetic rats
oxidative stress
lps induced
pi k akt
drug induced
endothelial cells
inflammatory response
immune response
toll like receptor