Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition.
Tuan VoBrad BaldersonKahli JonesGuiyan NiJoanna CrawfordAmanda MillarElissa TolsonMatthew SingletonMarija KojicThomas RobertsonShaun WaltersOnkar MulayDharmesh D BhuvaMelissa J DavisBrandon J WainwrightQuan NguyenLaura A GenovesiPublished in: Genome medicine (2023)
Our data highlight the power of using spatial transcriptomics to characterise the response of a tumour to a targeted therapy and provide further insights into the molecular and cellular basis underlying the response and resistance to CDK4/6 inhibitors in SHH MB.