Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus .
Lin KongRongyuan ZhangJunyi GongHuan WangLingyu ZhaiDongfeng DangQian LiuZheng ZhaoBen Zhong TangPublished in: Chemical communications (Cambridge, England) (2024)
A cationic aggregation-induced emission photosensitizer (AIE-PS) MNNPyBB has been reported to have antibacterial effects against both Gram-positive and Gram-negative bacteria. The bacterial kill mechanism has been investigated and elucidated. In a methicillin-resistant Staphylococcus aureus subcutaneous infection model, wound closure has been achieved with normal re-epithelialization and preserved skin morphology.
Keyphrases
- methicillin resistant staphylococcus aureus
- photodynamic therapy
- wound healing
- staphylococcus aureus
- silver nanoparticles
- gram negative
- anti inflammatory
- fluorescent probe
- soft tissue
- living cells
- stem cells
- atomic force microscopy
- mesenchymal stem cells
- mass spectrometry
- surgical site infection
- cell therapy
- smoking cessation