A mitochondria-targeting dinuclear Ir-Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells.
Cheng ZhangRuilin GuanXinxing LiaoCheng OuyangThomas W ReesJiangping LiuYu ChenLiangnian JiHui ChaoPublished in: Chemical communications (Cambridge, England) (2019)
A mitochondria-targeting hetero-binuclear Ir(iii)-Ru(ii) complex was developed as a photoactivated chemotherapy (PACT) and photodynamic therapy (PDT) bifunctional agent to achieve a synergistic effective therapeutic outcome for the therapy of cisplatin-resistant tumour cells.
Keyphrases
- photodynamic therapy
- induced apoptosis
- cancer therapy
- cell cycle arrest
- cell death
- fluorescence imaging
- endoplasmic reticulum stress
- locally advanced
- squamous cell carcinoma
- reactive oxygen species
- oxidative stress
- bone marrow
- mesenchymal stem cells
- radiation therapy
- endoplasmic reticulum
- highly efficient
- energy transfer
- rectal cancer
- replacement therapy
- quantum dots