Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase-deficient renal cell carcinoma.

Jiayu LiangGuangxi SunXiuyi PanMengni ZhangPengfei ShenSha ZhuJinge ZhaoLinmao ZhengJunjie ZhaoYuntian ChenXiaoxue YinJunru ChenXu HuYuhao ZengJianhui ChenYongquan WangZhihong LiuJin YaoMinggang SuRui HuangBanghua LiaoQiang WeiXiang LiQiao ZhouJiyan LiuYali ShenZhenhua LiuNi ChenHao ZengXingming Zhang

Published in: Genome medicine (2023)

Overall, our study demonstrated the genomic, epigenomic, and transcriptomic features of metastatic lesions in FH-RCC and revealed their early evolutionary trajectory. These results provided multi-omics evidence portraying the progression of FH-RCC.

Keyphrases

renal cell carcinoma
single cell
squamous cell carcinoma
small cell lung cancer
rna seq
copy number
genome wide
dna methylation