Contractile Force of Transplanted Cardiomyocytes Actively Supports Heart Function After Injury.

Tim Stüdemann Judith RössingerChristoph MantheyBirgit GeertzRajiven SrikantharajahConstantin von BibraAya ShibamiyaMaria KöhneAntonius Wiehler J Simon Wiegert Thomas Eschenhagen Florian Weinberger

Published in: Circulation (2022)

Our optogenetic approach demonstrates that transplanted cardiomyocytes can actively participate in heart function, supporting the hypothesis that the delivery of new force-generating myocardium can serve as a regenerative therapeutic strategy.

Keyphrases

single molecule
heart failure
stem cells
mesenchymal stem cells
atrial fibrillation
skeletal muscle
high glucose
smooth muscle
tissue engineering
bone marrow