Direct and indirect impact of SARS-CoV-2 on the brain.
Jean Pierre Schatzmann PeronPublished in: Human genetics (2023)
Although COVID-19 is mostly a pulmonary disease, it is now well accepted that it can cause a much broader spectrum of signs and symptoms and affect many other organs and tissue. From mild anosmia to severe ischemic stroke, the impact of SARS-CoV-2 on the central nervous system is still a great challenge to scientists and health care practitioners. Besides the acute and severe neurological problems described, as encephalopathies, leptomeningitis, and stroke, after 2 years of pandemic, the chronic impact observed during long-COVID or the post-acute sequelae of COVID-19 (PASC) greatly intrigues scientists worldwide. Strikingly, even asymptomatic, and mild diseased patients may evolve with important neurological and psychiatric symptoms, as confusion, memory loss, cognitive decline, chronic fatigue, associated or not with anxiety and depression. Thus, the knowledge on the correlation between COVID-19 and the central nervous system is of great relevance. In this sense, here we discuss some important mechanisms obtained from in vitro and in vivo investigation regarding how SARS-CoV-2 impacts the brain and its cells and function.
Keyphrases
- sars cov
- cognitive decline
- respiratory syndrome coronavirus
- healthcare
- drug induced
- liver failure
- coronavirus disease
- mental health
- cerebral ischemia
- atrial fibrillation
- end stage renal disease
- induced apoptosis
- white matter
- ejection fraction
- respiratory failure
- primary care
- early onset
- resting state
- chronic kidney disease
- newly diagnosed
- cerebrospinal fluid
- working memory
- physical activity
- functional connectivity
- peritoneal dialysis
- health information
- multiple sclerosis
- signaling pathway
- blood brain barrier
- extracorporeal membrane oxygenation
- general practice