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Matrine combined with cisplatin synergistically inhibited urothelial bladder cancer cells via down-regulating VEGF/PI3K/Akt signaling pathway.

Xiao-Zhong LiaoLan-Ting TaoJia-Hui LiuYue-Yu GuJun XieYuling ChenMei-Gui LinTao-Li LiuDong-Mei WangHai-Yan GuoSui-Lin Mo
Published in: Cancer cell international (2017)
Our results suggested that the combination of matrine and cisplatin could synergistically inhibit the UBC cells' proliferation through down-regulating VEGF/PI3K/Akt signaling pathway, indicating that matrine may serve as a new option in the combinative therapy in the treatment of UBC.
Keyphrases
  • pi k akt
  • signaling pathway
  • cell cycle arrest
  • induced apoptosis
  • vascular endothelial growth factor
  • endothelial cells
  • epithelial mesenchymal transition
  • cell proliferation
  • spinal cord injury
  • high grade
  • stem cells