Deep learning using a biophysical model for robust and accelerated reconstruction of quantitative, artifact-free and denoised R 2 * images.

RoAR is trained to recognize the macroscopic magnetic field inhomogeneities directly from the input magnitude-only mGRE data and eliminate their effect on R 2 ∗ measurements. RoAR training is based on the biophysical model and does not require ground-truth R 2 * maps. Since RoAR utilizes signal information not just from individual voxels but also accounts for spatial patterns of the signals in the images, it reduces the sensitivity of R 2 * maps to the noise in the data. These features plus high computational speed provide significant benefits for the potential usage of RoAR in clinical settings.