Efficacy of administered mesenchymal stem cells in the initiation and co-ordination of repair processes by resident disc cells in an ovine (Ovis aries) large destabilizing lesion model of experimental disc degeneration.

Cindy C ShuAndrew DartRobin BellChristina DartElizabeth ClarkeMargaret M SmithChristopher B LittleJames Melrose

Published in: JOR spine (2018)

Administered MSCs produced recovery in degenerate IVDs, restored disc height, composition, biomechanical properties, down regulated MMPs and fibrosis, strongly supporting the efficacy of MSCs for disc repair.

Keyphrases

mesenchymal stem cells
umbilical cord
induced apoptosis
body mass index
bone marrow
patient safety
cell cycle arrest
stem cells
signaling pathway
cell proliferation
endoplasmic reticulum stress