Validation of a surgical model for posthepatectomy liver failure in rats.

Andrea LundMichelle MeierKasper Jarlhelt AndersenMarie Ingemann PedersenAnders Riegels KnudsenJakob KirkegårdFrank Viborg Mortensen

Published in: Animal models and experimental medicine (2023)

Based on the GDS and liver-specific biochemistry, we concluded that the model of 90% PH seems to be a proper model for investigating PHLF in rats. As a high GDS is associated with increased mortality, the GDS appears to be valuable in detecting lethal outcomes caused by PHLF in rats.

Keyphrases

liver failure
hepatitis b virus
type diabetes
coronary artery disease
cardiovascular events
metabolic syndrome
adipose tissue
risk factors
insulin resistance
glycemic control