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Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells.

Yahui DingXiaoping ChenCan LiuWeizhi GeQin WangXin HaoMengmeng WangYue ChenQuan Zhang
Published in: Journal of hematology & oncology (2021)
These findings firstly revealed novel manner to induce ferroptosis through ubiquitination of GPX4 and provided mechanism for GPX4 inducing mitochondria-mediated apoptosis through up-regulation of EGR1 in TNBC cells. Moreover, compound 13 deserves further studies as a lead compound with novel mode of action for ultimate discovery of effective anti-TNBC drug.
Keyphrases
  • cell death
  • cell cycle arrest
  • small molecule
  • breast cancer cells
  • induced apoptosis
  • protein protein
  • endoplasmic reticulum stress
  • pi k akt
  • single cell
  • signaling pathway
  • reactive oxygen species
  • adverse drug