Functional characterization of 27 CYP3A4 variants on macitentan metabolism in vitro.

Ying-Hui LiXiang-Ran LuQian-Meng LinHuan-le HuangXiao-Long LiangJian-Ping CaiJu CuiGuo-Xin Hu

Published in: The Journal of pharmacy and pharmacology (2019)

Twenty-seven CYP3A4 protein variants displayed different catalytic characteristics towards macitentan in vitro, especially CYP3A4.5, .17, .20, .23. It is important to pay more attention to the dosage of macitentan in order to get better treatment for pulmonary arterial hypertension.

Keyphrases

pulmonary arterial hypertension
pulmonary artery
pulmonary hypertension
copy number
health insurance
amino acid
protein protein
gene expression
dna methylation
coronary artery
genome wide
replacement therapy