Chemotherapy-induced phlebitis via GBP5/NLRP3 axis and the therapeutic effect of Aescin.

Peng LiuLichun YeYongshen RenGuodun ZhaoYun ZhangShaojuan LuQiang LiChen WuLijie BaiZhongyun ZhangZhongqiu ZhaoZhaohua ShiShijin YinMaochuan LiaoZhou LanJing Feng Lvyi Chen

Published in: British journal of pharmacology (2022)

These findings suggest that GBP5 is an important regulator of NLRP3 inflammasome in CIP mouse model. Our work further reveals that aescin may serve as a promising candidate in the clinical treatment of CIP.

Keyphrases

nlrp inflammasome
chemotherapy induced
mouse model
transcription factor
combination therapy
replacement therapy