Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis.
Cristina de DiosXenia AbadinVicente Roca-AgujetasMarina Jimenez-MartinezAlbert MoralesRamon TrullasMontserrat MariAnna ColellPublished in: Translational neurodegeneration (2023)
Changes in intracellular cholesterol levels differentially regulate the inflammasome-mediated immune response in microglia and neuronal cells. Given the microglia-neuron cross-talk in the brain, cholesterol modulation should be considered a potential therapeutic target for AD treatment, which may help to block the aberrant and chronic inflammation observed during the disease progression.
Keyphrases
- low density lipoprotein
- inflammatory response
- immune response
- neuropathic pain
- induced apoptosis
- cerebral ischemia
- oxidative stress
- cell cycle arrest
- toll like receptor
- lps induced
- white matter
- dendritic cells
- cell proliferation
- signaling pathway
- endoplasmic reticulum stress
- human health
- brain injury
- drug induced
- smoking cessation