Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect.

Catharine E KrebsAnil P S OriAnnabel VreekerTimothy WuRita M CantorMarco P M BoksRene S KahnLoes M Olde LoohuisRoel A Ophoff

Published in: Psychological medicine (2019)

These findings suggest that BD is associated with minimal changes in whole blood gene expression independent of medication use but emphasize the importance of accounting for medication use and cell type heterogeneity in psychiatric transcriptomic studies. The results of this study add to mounting evidence of lithium's cell signaling and immune-related mechanisms.

Keyphrases

single cell
bipolar disorder
gene expression
rna seq
major depressive disorder
dna methylation
mental health
solid state
cell therapy
bone marrow