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Genetic Diversity and in vitro Activity of Aztreonam/Avibactam and Ceftazidime/Avibactam Against Carbapenem-Resistant Enterobacterales : A Multi-Center Study in Southwest China.

Shan SunKai ChenXuehua KongWenjun TianSi-Qiang Niu
Published in: Infection and drug resistance (2022)
The distribution features of carbapenemase genes in Chongqing were comprehensively illustrated in terms of species and sources of CRE for the first time in this multi-center study that covered all the geographical locations across Chongqing. ATM/AVI showed superior activity against all CRE isolates regardless of their genotype, whereas CAZ/AVI was active against almost all KPC-producers.
Keyphrases
  • genetic diversity
  • klebsiella pneumoniae
  • gram negative
  • multidrug resistant
  • gene expression
  • escherichia coli
  • genome wide
  • oxidative stress
  • dna repair
  • dna damage response
  • acinetobacter baumannii