Chlorogenic acid alleviates the reduction of Akt and Bad phosphorylation and of phospho-Bad and 14-3-3 binding in an animal model of stroke.

Murad-Ali Shah Ju-Bin Kang Myeong Ok Kim Phil Ok Koh

Published in: Journal of veterinary science (2022)

The results of the present study showed that chlorogenic acid activates phospho-Akt and phospho-Bad and promotes the interaction between phospho-Bad and 14-3-3 during MCAO damage. In conclusion, chlorogenic acid exerts neuroprotective effects by activating the Akt-Bad signaling pathway and maintaining the interaction between phospho-Bad and 14-3-3 in ischemic stroke model.

Keyphrases

signaling pathway
cell proliferation
pi k akt
atrial fibrillation
epithelial mesenchymal transition
induced apoptosis
oxidative stress
brain injury
endoplasmic reticulum stress
protein kinase