Polygenic risk score of metabolic dysfunction-associated steatotic liver disease amplifies the health impact on severe liver disease and metabolism-related outcomes.

Lushan XiaoYan LiChang HongPengcheng MaHongbo ZhuHao CuiXuejing ZouJiaren WangRuining LiJingzhe HeShengxing LiangZeyang LiLin ZengLi Liu

Published in: Journal of translational medicine (2024)

High PRS of MASLD GWAS amplified the impact of MASLD on SLD and metabolism-related outcomes, thereby refining the process of identification of individuals at high risk of MASLD. Supplementation of this process with relevant genetic backgrounds may lead to more effective MASLD prevention and management.

Keyphrases

healthcare
public health
mental health
oxidative stress
early onset
genome wide
type diabetes
metabolic syndrome
risk assessment
skeletal muscle
insulin resistance