Inhibition of inflammation by minocycline improves heart failure and depression-like behaviour in rats after myocardial infarction.

Hong-Wei WangMonir AhmadRami JadayelFatimah NajjarDiane LagaceFrans H H Leenen

Published in: PloS one (2019)

Rats post myocardial infarction develop systemic inflammation, heart failure and depression-like behaviour that are all attenuated by minocycline. Targeting (neuro) inflammation may represent new therapeutic strategy for patients with heart failure and depression.

Keyphrases

heart failure
depressive symptoms
oxidative stress
left ventricular
sleep quality