A retrospective investigation of the relationship between neuroblastoma response to anti-GD2 monoclonal antibodies and exposure to opioids for pain management.

Kyle J MorganAndrew DudasWayne L FurmanM Beth McCarvilleBarry L ShulkinZhaohua LuHimani DarjiDoralina L Anghelescu

Published in: Pediatric blood & cancer (2022)

Our study found no statistically significant correlation between opioid consumption and natural killer (NK) cell-mediated killing of NB cells as measured by effects on tumor volume/tumor load.

Keyphrases

pain management
nk cells
chronic pain
induced apoptosis
cell cycle arrest
cell death
oxidative stress
cell proliferation