Reversal of apixaban and rivaroxaban with andexanet alfa prior to invasive or surgical procedures.

Paige Garber BradshawShaun Patrick KeeganMolly Elizabeth DroegeNicole Jade Harger DykesNeil Edward ErnstMadeline Jane FoertschAmy Teres MakleyEric William MuellerCarolyn Dosen PhilpottVasisht SrinivasanJessica Brooke WinterMichael D GoodmanChristopher Allen Droege

Published in: Pharmacotherapy (2022)

Andexanet alfa may be used for urgent or emergent reversal of apixaban and rivaroxaban peri-procedurally with promising hemostatic outcomes. Further prospective, comparative clinical research is warranted.

Keyphrases

venous thromboembolism
atrial fibrillation
replacement therapy
pulmonary embolism
type diabetes
smoking cessation
metabolic syndrome