Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment.
Mihai-Vlad ValuLiliana Cristina SoareCatalin DucuSorin Georgian MogaDenis NegreaEmanuel VamanuTudor-Adrian BalseanuSimone CarradoriLucian HritcuRazvan Stefan BoiangiuPublished in: Journal of fungi (Basel, Switzerland) (2021)
Hericium erinaceus (H. erinaceus) is a rare and appreciated fungal species belonging to the division Basidiomycota used for centuries in traditional Chinese medicine for its medicinal value. This species of mushrooms brings the most diverse benefits for the human body, and can have beneficial effects for treating Alzheimer's disease (AD). This study investigated whether ethanolic extract from the fungal biomass of H. erinaceus enhances cognitive function via the action on cholinergic neurons using the scopolamine (SCOP)-induced zebrafish (Danio rerio) model of memory impairment. The ethanolic extract from the fungal biomass of H. erinaceus was previously obtained using an ultrasonic extraction method (UE). The administration of H. erinaceus extract to zebrafish, with a pattern of AD induced by scopolamine, showed an improvement in memory evaluated by behavioral and biochemical tests on brain tissue. These results suggest that H. erinaceus has preventive and therapeutic potentials in managing memory deficits and brain oxidative stress in zebrafish with AD.
Keyphrases
- oxidative stress
- diabetic rats
- working memory
- anti inflammatory
- cognitive impairment
- endothelial cells
- high glucose
- traumatic brain injury
- dna damage
- wastewater treatment
- ischemia reperfusion injury
- white matter
- induced apoptosis
- multiple sclerosis
- spinal cord
- cognitive decline
- spinal cord injury
- drug induced
- subarachnoid hemorrhage
- atomic force microscopy
- mass spectrometry
- stress induced