Polygenic Risk Score to Identify Subclinical Coronary Heart Disease Risk in Young Adults.

Quinn S Wells Minoo Bagheri Aaron W Aday Deepak K GuptaChristian M ShafferWei-Qi Wei Nataraja Sarma Vaitinadin Sadiya S Khan Philip Greenland Thomas J WangC Michael SteinDan M Roden Jonathan D Mosley

Published in: Circulation. Genomic and precision medicine (2021)

Among young adults, a PRS improved model discrimination for coronary atherosclerosis, but improvements were smaller than those associated with modifiable risk factors.

Keyphrases

young adults
risk factors
coronary artery disease
childhood cancer
coronary artery
cardiovascular disease
type diabetes
heart failure