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Endothelial LAT1 (SLC7A5) Mediates S-Nitrosothiol Import and Modulates Respiratory Sequelae of Red Blood Cell Transfusion In Vivo.

Hongmei ZhuRichard L AutenAugustus Richard WhortonStanley Nicholas MasonCheryl B BockGary T KuceraZachary T KelleherAaron T VoseTimothy J McMahon
Published in: Thrombosis and haemostasis (2024)
 This is the first study showing a role for SNO transport by LAT1 in ECs in a genetic mouse model. We provide the first direct evidence for the coordination of RBC SNO export with EC SNO import via LAT1. SNO flux via LAT1 modulates RBC-EC sequestration in lungs after transfusion, and its disruption impairs blood oxygenation by the lung.
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